邢唷> MOL欹[ 餜@bjbj4B螑螑! rrMMMMMaaa8,$a_AW c${ #P-MkAAkkMMXkMMkJr@[eKVfa!b/0_jm# m#rrm#M^Tkkkkkkkkkk_kkkkm#kkkkkkkkkr : Robert Diasio, MD/PhD, Professor of PharmacologyMy research interests over the past 30 years have been to examine the pharmacology(preclinical to clinical) of 5-Fluorouracil (5-FU) chemotherapy and the role of genetic factors in determiningboth toxicity and efficacy of 5-FU drugs. My laboratory was one of the first to demonstrate the importanceof the catabolic pathway in the metabolism and pharmacokinetics of 5-FU with initial studies in hepatocytesand subsequent studies in humans. Later studies in my lab purified and characterized humandihydropyrimidine dehydrogenase (DPD), which then permitted partial sequencing of the amino acid structure,which in turn led to isolation of the cDNA and eventually the structure of the gene for DPD, DPYD, with additional studies爄dentifying the contribution of various DPYD variants. More recently my laboratory has evaluated the regionsregulating DPYD expression including both the promoter and enhancer regions with demonstration of variantscontributing to decreased DPD activity. Clinical studies with patients who experienced life-threateningtoxicity after exposure to 5-FU has led to the development of genomic tests to predict DPD deficiency as well asimproving individualization of 5-FU therapy. Haidong Dong, MD/PhD, Associate Professor of ImmunologyResearch interest: cancer immunology. Current research objectives and goals: (1) Evaluating and monitoring tumor-reactive T cell responses in cancer patients and their responses to cancer therapy (immune checkpoint blockade, chemotherapy, radiation therapy, surgery). (2) Defining intracellular signaling pathways of immune checkpoint molecules in T cell activation, differentiation and survival. (3) Defining molecular mechanisms of tumor chemoresistance and radio resistance. (4) Developing and evaluating novel synergy combinations in cancer therapy. Zhenkun Lou, PhD, Professor of PharmacologyMy lab has made major contributions to understanding the cellular mechanisms that maintain genomic stability. The DNA damage response pathway is a series of biochemical reactions that are critical for preserving genomic integrity. Through complex signal transduction events, the DNA damage response pathway senses DNA damage and triggers cellular responses, including activation of cell cycle checkpoints and DNA repair. Understanding the DNA damage response pathway has important implications for human health, particularly cancer development and treatment. Genomic instability is a hallmark and driving force of tumorigenesis, as evidenced by the fact that many factors involved in the DNA damage response, such as ATM, BRCA1, and p53, are mutated in various of human cancers. Because individual tumors often have unique defects in the DNA damage response pathway, insight into the basic mechanisms by which cells repair different DNA lesions could guide individualized therapy. A classic example is the use of PARP inhibitors to treat cancers with BRCA1 and BRCA2 mutations. My research team is also interested in how dysregulation of energy of cellular energy metabolism affects cancer cell proliferation and metabolic diseases, with the focus on the AMPK-SIRT1 pathway.Ping Yang, MD/PhD, Professor of EpidemiologyResearch interest: clinical and genomic epidemiology, particularly in optimal study design and cancer outcome research. Her long-standing research interests are in the etiology and outcomes of cancer, especially genetic predisposition and gene-environment interactions in lung cancer prognoses that focus on both quantity and quality of life. Since joining Mayo Clinic in the fall of 1996, she has initiated numerous research projects in lung cancer and a few in other malignant diseases. With 20 years of efforts and support from many colleagues, she has built a prospectively followed lung cancer cohort (over 20,000 patients of which ~2000 having small cell lung cancer) with annotated biospecimens and particularly the detailed clinical and routine follow-up data on treatments, disease progression, recurrence, and comorbid conditions, as well as cause of death. She has assembled a multidisciplinary, multispecialty research team, and worked with them closely in the processes from designing, conducting, and completing numerous projects. Dev Mukhopadhyay, PhD, Professor of Biochemistry and Molecular BiologyDebabrata (Dev) Mukhopadhyay, Ph.D., has a broad background in tumor microenvironment with training and expertise in angiogenesis, cancer, cardiovascular diseases and diabetes. Dr. Mukhopadhyay and his team are using pancreatic and renal cancer disease models to examine how tumors develop and particularly how they induce the angiogenic response that is essential for their survival.PanosAnastasiadis, PhD, Professor of Cancer Biology/Associate Professor of Biochemistry and Molecular BiologyThe laboratory of Panagiotis (Panos) Z. Anastasiadis, Ph.D., is interested in elucidating the role of cadherin adhesion receptors, polarity proteins and Rho GTPases in human cancer. In particular, the lab is investigating adhesion-mediated signaling events that regulate cell growth, suppress cell motility and invasiveness, and promote the reorganization of the actin cytoskeleton.Kun Ling, PhD, Associate Professor of Biochemistry and Molecular BiologyThe laboratory of Kun Ling, Ph.D., is interested in the mechanisms modulating cell communications. The status of cells in association with the surrounding microenvironment, including attaching to and communicating with the neighboring cells and underlying matrix, is essential for their morphology and behavior. In turn, it affects numerous life events, such as embryogenesis, differentiation, angiogenesis, tissue repair, immune response and cancer progression. Dr. Ling's laboratory is focused on the roles of phosphoinositide signaling, especially the type I phosphatidylinositol phosphate kinases, in cell adhesion, migration and primary cilia-mediated cell communication, as well as in the related human diseases.Haojie Huang, PhD, Professor of Biochemistry and Molecular Biology and UrologyDr. Huang's research focuses on regulation of the functions of transcription regulatory proteins by mechanisms such as phosphorylation, acetylation, ubiquitination and protein-protein interaction and these proteins' roles in initiation and progression of cancer, especially prostate cancer. A new direction in his lab is to investigate the biogenesis and functions of enhancer RNAs (eRNAs) and their role in cancer development and progression.Mark McNiven, PhD, Professor of Biochemistry and Molecular BiologyDr. McNiven conducts research focused on diseases related to liver and the pancreas, such as pancreatic cancer, steatotic liver, and liver cancer. His research investigates how cytoskeletal and membrane dynamics support basic cellular functions during healthy and disease states. Dr. McNiven strives to understand how liver and pancreas cells synthesize, transport, signal and degrade growth factor receptors that are essential to tumor growth and migration. Dr. McNiven also studies how liver cells store and utilize excess fat and how damage caused by factors such as alcohol can lead to fatty liver disease.Keith Knutson, PhD, Professor of ImmunologyThe research interests of Dr. Knutson focus on the immunology and immunotherapy of breast and ovarian cancers, both the basic immunobiology and clinical translation, including clinical trials using vaccines and adoptive T-cell therapy. Daniel Billadeau, PhD, Professor of Biochemistry and Molecular Biology and ImmunologyDevelopment of novel mouse models of pancreatic cancer to understand the role of a protein in tumor development and sensitivity to chemotherapy Discovery of new targets in pancreatic cancer with the aim of developing new anti-cancer molecules for testing in animal models and human cancers Uncovering the proteins and signaling pathways that contribute to pancreatic cancer stem cell self-renewal and chemoresistance Understanding the immune system using genetic knockout mouse models and in vitro human cell systems, with an emphasis on T cell and natural killer cell biology and their role in immunodeficiency Elucidating the function of molecules involved in receptor trafficking that contribute to normal and pathological disease states Edward Leof, PhD, Professor of Biochemistry and Molecular Biology and Medicine The laboratory of Edward B. Leof, Ph.D., studies the role(s) of transforming growth factor beta (TGF-) family members in organ fibrosis, glioblastoma and ovarian cancer. 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