在国际上率先报道了siRNA量子点纳米载体系统，阐明了siRNA高效转染纳米载体结构特征与作用机制；探明了多糖纳米材料靶向作用肿瘤细胞膜脂质层的抗肿瘤作用机理；筛选鉴定了胶质瘤血管抑制作用靶点及作用机制👨🏽⚕️。已在国际权威期刊JACS、ACS nano、Biomacromolecules👜、Journal Material Chemistry👩🦼➡️、European Journal of Cancert.等杂志发表SCI科研论文近20篇。论文被他引超过600次👱🏻♂️，单篇论文他引180余次👍。其中在JACS, ACS nano👱♀️，European Journal of Cancer发表的论文被美国癌症研究所重点报道，在ACS nano发表论文被列为当期重点推荐文章，并在该杂志年度总结中作为亮点论文介绍。最近发表在Recent Pat Biotechnol.上论文被列为该研究方向TOP20 排名第一论文。申请发明专利6项💆🏼，授权2项🔭。
已发表论文🍖🥷：
[1] Qi L*, Shao W, Shi D. JAM-2 siRNA intracellular delivery and real-time imaging by proton-sponge coated quantum dots. J. Mater. Chem. B, 2013, Advance Article. DOI: 10.1039/C2TB00027J. (IF:5.968)
[2] Qi L*, Wu S, Zheng S, Fu H, Cui D. Cell permeable magnetic nanoparticles for siRNA delivery. Biomolecules, 2012, 13(9), 2723-2730. (IF:5.47).
[3] Shao W, Zheng S, Qi L*. Recent patents on nanosensor for tumor biomarker detection. Nano Biomed. Eng. 2011, 3(1):66-72.
[4] Qi L, Zheng S, Lin B. Recent patents on imaging nanoprobes for brain tumor diagnosis and therapy. Recent Pat Biotechnol. 2010 Jun 1;4(2):130-5. (IF:5.2)
[5] Lin, B, Jin, S, Wang, J, Qi L,et.al Meeting report: the 2009 Westlake International Conference on Personalized Medicine,《OMICS》, V0l.13(4), 2009.
[6] Qi L, Gao X. Quantum Dot-Amphipol Nanocomplex for Intracellular Delivery and Real-Time Imaging of siRNA. ACS nano, 2008, 2(7), 1403–1410 (IF: 11).
[7] Yezhelyev M.V., Qi L, O’Regan R.M., Nie S., Gao X. Proton-sponge-coated quantum dots for siRNA delivery and intracellular imaging. J. Am. Chem. Soc. 2008, 130, 9006-9012 (IF:7.9)
[8] Qi L, Gao X. Emerging application of quantum dots for drug delivery and therapy. Expert Opin. Drug Deliv. 2008; 5:263-267 (,IF:4.8).
[9] Qi L, Pal S, Dutta P, Seehra M, Pei M. Morphology controllable nanostructured chitosan matrix and its cytocompatibility. J. Biomed. Mater. Res. A. 2007 Dec. 18 online (IF:2.5).
[10] Qi L*, Xu Z, Chen M. In vitro and in vivo suppression of growth of human hepatoma BEL7402 cells by chitosan nanoparticles. Eur. J. Cancer 2007; 43:184-93 (IF:5.2).
[11] Qi L, Xu Z. In vivo antitumor activity of chitosan nanoparticles. Bioorg. Med. Chem. Lett. 2006, 16, 4243-5 (IF2.6).
[12] Qi L, Xu Z, Li Y, Jiang X, Han X. In vitro effects of chitosan nanoparticles on proliferation of human gastric carcinoma cell line MGC803. World J Gastroenterol. 2005; 11(33): 5136-5141 (IF:3.3).
[13] Qi L, Xu Z, Jiang X, Li Y, Wang M. Cytotoxic activities of chitosan nanoparticles and copper-loaded nanoparticles. Bioorg. Med. Chem. Lett. 2005; 15: 1357-1399 (IF:2.6).
[14] Qi L, Xu Z, Jiang X, Hu C, Zou X. Preparation and antibacterial activity of chitosan nanoparticles, Carbohydr. Res. 2004; 339 (16): 2693-2700 (IF:2.5).
[15] Qi L, Xu Z. Lead sorption from aqueous solutions on chitosan nanoparticles, Colloids Surfaces A: Physicochem Eng Aspects 2004; 251: 183-190 (IF:2.2).
[16] Qi L, Dutta P, Pas S, Seehra M, Pei M. Preparation and characterization of chitosan nanocrystal. NSTI Nanotech 2007, Bio Nano Material & Tissues Syposium, Santa Clara, California, May 20-24, 2007, abstract number 755.
[17] Qi L, Dutta P, Pas S, Seehra M, Pei M. Chitosan nanaocrystals: A potential Biomaterial for tissue engineering application. NSTI Nanotech 2007, Bio Nano Material & Tissues Syposium, Santa Clara, California, May 20-24, 2007, abstract number 770.
[18] Gao X. Qi L. Quantum dot for efficient delivery and real-time imaging of siRNA. ACS 236th National meeting, Aug. 17-21, 2008.
承担课题🪵：
1．国家自然科学基金 批准号:30900345，新型分子影像siRNA纳米载体系统的构建及其在乳腺癌应用基础研究。2010年1月~2012年12月🏃♀️➡️。
2．2009年国家教育部博士点基金-新教师类（20090101120155，MiR-127 和MiR-433在神经胶质瘤发生发展中的功能性研究🌼，2010-01-01~2011-12-31）🚎。
3．教育部留学人员回国启动资金，新型分子影像siRNA纳米载体系统靶向转染脑胶质瘤细胞分子机理研究,2010.12-2012.12 。
专利🛀🏿：
PCT/CN2004/000774 Xu Z🚴🏿♀️，Qi L. Fabrication of chitosan nanoparticles as anticancer agents.
CN200410016440.2 Xu Z，Qi L. Hu C. Xia M. 一类多糖类抗菌纳米材料制备及应用🍩。
CN200410016441.7 Xu Z🌽，Qi L. Hu C. Xia M. 一类多糖类抗癌纳米材料制备及应用🆔。
200910096432.6 亓立峰，靶向识别肿瘤细胞的纳米药物载体材料及其制备和应用👩🏼🦰。
201110067159.1. 亓立峰，一种检测手足口病病原的纳米探针芯片及其应用方
法。
201210119028.8，亓立峰，一种靶向抑制胶质瘤细胞浸润和转移的方法及其应用。
