2001年获全国高中生物竞赛一等奖，2006年获四川大学生物技术学士学位，2011年获清华大学生物学博士学位。后于美国加州大学圣迭戈分校（UCSD）诺贝尔生理与医学奖得主实验室和新加坡科技局（A*STAR）从事博士后研究🌟。
2015年入职上海顺盈娱乐平台担任教授🧎♀️、课题组长(PI)。先后入选教育部高层次人才青年项目、中组部国家青年特聘专家👨🏼🔬、浙江省“千人计划”特聘专家、江苏省双创人才🤗、江西省双千人才计划😇。先后作为负责人承担国家重点研发计划、国家自然科学基金优秀青年基金、国家自然科学基金国际合作专项、国家生物药技术创新中心“揭榜挂帅”项目、江苏省重点研发计划等重要项目。
左为团队深入开展基于成体干细胞的肺、肾和心脏等重要脏器的再生修复🤏、功能增强及衰老逆转研究。提出器官再生是其发育过程重演的创新理论，开创了R-Clone药品级前体细胞分离扩增技术🫲🏽，负责三项国家卫健委干细胞临床研究备案项目，主导完成世界上首个肺前体细胞移植临床试验🏋🏽♂️。论文成果发表在Nature、Science Translational Medicine、AJRCCM🛼、EMBO Mol Med😑🧏♂️、Protein Cell等高水平期刊上, 单篇通讯作者论文被引超1700次。开发的全球首创肺前体细胞1类新药REGEND001获国家药监局批件进入II期临床💃🏼，目前已成功完成上百例患者受损肺脏的再生修复治疗。相关成果入选2018年中国医药生物技术年度十大进展⏳，2023年欧洲呼吸学会(ERS)发布的全球年度三项重要进展👮🏼🧘🏿♀️。个人2018年获国家刊物官方评选为“中国年度十大创新先锋”, 2020年获江苏医药科技进步奖(第一完成人) ，2021年入选中国“科学家创业先锋”榜单Top5, 2023年获蔚澜创新青年科学家奖，同年入选树兰基金会“生命科学新力量年度人物”👨🏼🏭。
Publications 代表性论著 （# corresponding author, 通讯作者）
1.
Wang Y*, Meng Z*, Liu M*, Zhou Y*, Chen D*, Zhao Y, Zhang T, Zhong N#, Dai X#, Li S#, Zuo W#. Autologous transplantation of P63+ lung progenitor cells for chronic obstructive pulmonary disease therapy. Sci. Transl. Med.16, eadi3360(2024). DOI:10.1126/scitranslmed.adi3360. IF=17.1 （headline story, recommended by Science）
2.
Hong X*, Nie H*, Deng J, Liang S, Chen L, Li J, Gong S, Wang G, Zuo W#, Hou F#, Zhang F#. WT1+ glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury. Theranostics. 2023 Feb 21;13(4):1311-1324. doi: 10.7150/thno.79326. PMID: 36923529; PMCID: PMC10008742. IF=12.4
3.
Liang C*, Zhao Z*, Liu S, Zhang T, Zuo W#. Single-cell transcriptome profiling of the vaginal epithelium reveals the heterogeneity of suprabasal cells. Precis Clin Med. 2023 Mar 20;6(1):pbad006. doi: 10.1093/pcmedi/pbad006. PMID: 37007744; PMCID: PMC10065133. IF=5.3
4.
Liu X*, Zhao Y*, Niu Y*, Xie Q , Nie H , Jin Y , Zhang Y , Lu Y , Zhu S , Zuo W# , Yu C#.Urinary single-cell sequence analyzes the urinary macrophage in different outcomes of membranous nephropathy. Clinical Kidney Journal. 2023. doi: 10.1093/ckj/sfad132. IF=5.86
5.
Nie H*, Zhao Z*, Zhou D, Li D, Wang Y, Ma Y, Liu X, Zuo W#. Activated SOX9+ renal epithelial cells promote kidney repair through secreting factors. Cell Prolif. 2023 Apr;56(4):e13394. doi: 10.1111/cpr.13394. Epub 2023 Jan 4. PMID: 36601693; PMCID: PMC10068929. IF=8.755
6.
Yang H*, Nie H*, Zhou D*, Wang Y#, Zuo W#. The Effect of Strict Lockdown on Omicron SARS-CoV-2 Variant Transmission in Shanghai. Vaccines (Basel). 2022 Aug 25;10(9):1392. doi: 10.3390/vaccines10091392. PMID: 36146469; PMCID: PMC9500677. IF=4.96
7.
Zhao Z*, Wang Y*, Wu Y*, Li D, Zhang T, Ma Y, Teng X, Zuo W#. Single-cell analysis defines the lineage plasticity of stem cells in cervix epithelium. Cell Regen. 2021 Nov 1;10(1):36. doi: 10.1186/s13619-021-00096-2. PMID: 34719766; PMCID: PMC8558147. IF=2.0
8.
Zhou Y*, Wang Y, Li D, Zhang T, Ma Y, Zuo W#. Stable Long-Term Culture of Human Distal Airway Stem Cells for Transplantation. Stem Cells Int. 2021;2021:9974635. Published 2021 Sep 16. doi:10.1155/2021/9974635. IF=5.13
9.
Wang X*, Zhao Y*, Li D, Feng Y, Xie Y, Zhou Y, Zhou M, Wang Y, Qu J, Zuo W#. Intrapulmonary distal airway stem cell transplantation repairs lung injury in chronic obstructive pulmonary disease. Cell Prolif. 2021 Jun;54(6):e13046. doi: 10.1111/cpr.13046. Epub 2021 May 7. PMID: 33960563; PMCID: PMC8168420. IF=8.76
10.
Wang Y*, Zhao Y*, Zhao Z*, Li D, Nie H, Sun Y, Feng X, Zhang T, Ma Y, Nie J, Cai G#, Chen X#, Zuo W#. Single-cell RNA-Seq analysis identified kidney progenitor cells from human urine. Protein Cell. 2021 Apr;12(4):305-312. doi: 10.1007/s13238-020-00816-5. Epub 2021 Jan 9. PMID: 33420958; PMCID: PMC8018990. IF=15.33
11.
Zhao Y*, Zhao Z*, Wang Y*, Zhou Y, Ma Y, Zuo W#. Single-Cell RNA Expression Profiling of ACE2, the Receptor of SARS-CoV-2. Am J Respir Crit Care Med. 2020 Sep 1;202(5):756-759. doi: 10.1164/rccm.202001-0179LE. Erratum in: Am J Respir Crit Care Med. 2021 Mar 15;203(6):782. PMID: 32663409; PMCID: PMC7462411. IF= 30.53
12.
Zhao Z*, Zhao Y*, Zhou Y*, Wang X, Zhang T, Zuo W#. Single-cell analysis identified lung progenitor cells in COVID-19 patients. Cell Prolif. 2020 Dec;53(12):e12931. doi: 10.1111/cpr.12931. Epub 2020 Oct 22. PMID: 33094537; PMCID: PMC7645905. IF=8.755
13.
Zhou YQ*, Shi Y*, Yang L*, Sun YF, Han YF, Zhao ZX, Wang YJ, Liu Y, Ma Y, Zhang T, Ren T, Dale TP, Forsyth NR, Jin FG, Qu JM#, Zuo W#, Xu JF#. Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection. EMBO Mol Med. 2020 Jan 9;12(1):e10233. doi: 10.15252/emmm.201810233. Epub 2019 Nov 29. PMID: 31782624; PMCID: PMC6949487. IF=14.26
14.
Wang Y*, Lu Y, Wu Y, Sun Y, Zhou Y, Ma Q, Zheng Y, Yu Q, Cao Y, Chen G, Zhang T, Dai X, Ren T, Ma Y#, Zuo W#. Alveolar Differentiation Potency of Human Distal Airway Stem Cells Is Associated with Pulmonary Pathological Conditions. Stem Cells Int. 2019 Jun 9;2019:7123078. doi: 10.1155/2019/7123078. PMID: 31281383; PMCID: PMC6590602. IF=5.13
15.
Shi Y*, Dong M*, Zhou Y*, Li W, Gao Y, Han L, Chen M, Lin H, Zuo W#, Jin F#. Distal airway stem cells ameliorate bleomycin-induced pulmonary fibrosis in mice. Stem Cell Res Ther. 2019 Jun 3;10(1):161. doi: 10.1186/s13287-019-1257-2. PMID: 31159891; PMCID: PMC6547529. IF=8.07
16.
Liu W*, Wang Y*, Sun Y*, Wu Y, Ma Q, Shi Y, He R, Zhang T, Ma Y#, Zuo W#, Wu Z#. Clonal expansion of hepatic progenitor cells and differentiation into hepatocyte-like cells. Dev Growth Differ. 2019 Apr;61(3):203-211. doi: 10.1111/dgd.12596. Epub 2019 Feb 20. PMID: 30786319. IF=2.1
17.
马煜🚵🏿，瞿介明🏀，左为#.呼吸系统干细胞临床研究进展.中国细胞生物学学报：1-9[2019-02-23].
18.
Ma Q*, Ma Y*, Dai X*, Ren T*, Fu Y, Liu W, Han Y, Wu Y, Cheng Y, Zhang T, Zuo W#. Regeneration of functional alveoli by adult human SOX9+ airway basal cell transplantation. Protein Cell. 2018 Mar;9(3):267-282. doi: 10.1007/s13238-018-0506-y. Epub 2018 Jan 17. PMID: 29344809; PMCID: PMC5829276. IF=15.33
19.
Ma Q*, Wang Y, Zhang T, Zuo W#. Notch-mediated Sox9+ cell activation contributes to kidney repair after partial nephrectomy. Life Sci. 2018 Jan 15;193:104-109. doi: 10.1016/j.lfs.2017.11.041. Epub 2017 Dec 2. PMID: 29198839. IF=6.78
20.
Ma Q*, Ma Y, Zhang T, Zuo W# (2017). Organ size control mechanism in animals. Science Bulletin. 62(7), 626-630. (in Chinese) IF=11.8
21.
Zhang T*#, Li S, Zuo W#. Landscape of protein domain interactome. Protein Cell. 2015 Aug;6(8):610-4. doi: 10.1007/s13238-015-0158-0. PMID: 25960191; PMCID: PMC4506283. IF=15.33
22.
Zuo W*, Zhang T, Wu DZ, Guan SP, Liew AA, Yamamoto Y, Wang X, Lim SJ, Vincent M, Lessard M, Crum CP, Xian W#, McKeon F#. p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration. Nature. 2015 Jan 29;517(7536):616-20. doi: 10.1038/nature13903. Epub 2014 Nov 12. PMID: 25383540; PMCID: PMC7095488. IF=64.8
23.
Zuo W, Chen YG. (2013). TGF-βsignaling in hematopoietic stem cells and leukemia. Cancer Hallmarks 1, 91-97.
24.
Zuo W, Huang F, Chiang J, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen YL, Deng HT, Feng XH, Luo SW, Gao CJ, Chen YG. (2013). c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of TGF-β type II receptor. Mol Cell 49 (3), 499-510 (“F1000”recommended ) IF=19.33
25.
Zhou H, Zuo W, Chen YG. (2012). Endocytosis.Molecular Cell Biology (book title)(invited book chapter), Tsinghua University Press.(in Chinese)
26.
Gao C. Cao WP, Bao L, Zuo W, Xie GM, Cai TT, Fu W, Zhang J, Wu W, Zhang X, Chen YG. (2010). Autophagy negatively regulates Wnt signaling by promoting Dishevelled degradation. Nat Cell Biol12(8), 781-790.
27.
Zhang W, Yuan J, Yang Y, Xu L, Wang Q, Zuo W, Fang X, Chen YG. (2010) Monomeric type I and type III transforming growth factor-β receptors and their dimerization. Cell Research 20(11), 1216-1223.
28.
Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X, Chen YG. (2009) Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization.Proc Natl Acad Sci USA106(37), 15679-15683
29.
Zuo W, Zhao XG, Chen YG (2009). SARS-CoV and lung fibrosis.Molecular Biology of the SARS-Coronavirus (book title)(invited book chapter), Springer Press.
30.
Zuo W, Chen YG (2009). Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity.Mol Biol Cell20(3), 1020-1029.
