1、上海顺盈娱乐平台附属第十人民医院骨科行政副主任、骨肿瘤科主任(Deputy Director of Department of Orthopaedics and Director of Department of Bone Oncology, Tenth People's Hospital, Tongji University)
2🧑🏻🚀、中华医学会骨科分会骨肿瘤学组委员(Member of the Bone Oncology Group of the Chinese Medical Association Orthopaedic Branch)
3、中国医药教育协会肢体肿瘤分会副主任委员(Vice chairman of Limb tumor branch of Chinese Medical Education Association )
4📸、上海市中西医结合学会骨伤科专委会创伤学组副组长(Deputy Head of Trauma Group, Shanghai Association of Integrated Traditional Chinese and Western Medicine)
5💜、上海市优秀学术带头人(Shanghai Excellent Academic Leader)
主持的主要科研项目(Leading major research projects)👨🏼⚖️:
1🖼、国家自然科学基金面上项目🚣🏼,82072963,Circ_0081001/DDX3X/KLF4分子轴促进骨肉瘤侵袭和转移的作用和机制研究,2021/1/1-2024/12/31🤷🏽♀️,55万元,在研,主持👮♂️,(National Natural Science Foundation, NSFC 82072963)
2𓀙、国家自然科学基金面上项目,81872174、LncRNA ODRUL/miR-6874-3p/IL-6通路促进骨肉瘤侵袭⇢、转移的作用及机制研究、2019/1/1-2022/12/31,57万元、在研、主持(National Natural Science Foundation, NSFC 81872174 )。
3、国家自然科学基金面上项目,81572630、长链非编码RNA OMRUL调控ABCB1介导骨肉瘤多药耐药发生💷、发展的分子机制研究🤴🏽、2016/01-2019/12、60万元、结题、主持(National Natural Science Foundation, NSFC 81572630)。
4、国家自然基金青年项目👰♂️,30700850🌙、应用RNA 干扰技术双通道下调Bcl-2 和cyclinD1 基因增强耐药骨肉瘤化疗敏感性的研究💹💁🏻♂️、2008/01-2010/12、16万元、已结题🚗、主持(National Natural Science Foundation, NSFC 30700850)💆♀️。
5🧂、上海市科委项目(优秀学术带头人项目)🤛🏿,19XD1402900,骨肿瘤保肢及其功能重建关键技术创新与应用🚵🏿、2019/05-2022/04、40万元、在研👨🏼🌾、主持(Shanghai Excellent Academic Leadership Program, 19XD1402900)。
6、上海市科委项目(浦江人才计划)🤸🏿♀️,13PJD023、髓腔内壁形态改变后骨-骨水泥界面的仿真形态学♻️、机械微力学及生物学作用机制的研究、2013/09-2015/08、20万元、已结题、主持(Shanghai Pu-Jiang Talent Program, 13PJD023)。
近五年发表的代表性论著(Representatives published in the past five years)🍓:
1、Zhang CL#, Zhu KP, Ma XL. Antisense lncRNA FOXC2-AS1 promotes doxorubicin resistance in osteosarcoma by increasing the expression of FOXC2. Cancer Lett. 2017;396:66-75.
2、Zhang CL#, Hu JP, Zhu KP, Cai T, Ma XL. Survival, complications and functional outcomes of cemented megaprostheses for high-grade osteosarcoma around the knee. Int Orthop. 2018;42(4):927-938.
3、Zhang CL#, Zeng BF, Zhu KP, Zhang L, Hu JP. Limb salvage for malignant bone tumours of distal tibia with dual ipsilateral vascularized autogenous fibular graft in a trapezoid-shaped array with ankle arthrodesis and preserving subtalar joint. Foot Ankle Surg. 2019;25(3):278-285.
4、Zhang CL, Hu J, Jiang Y, Tan S, Zhu K, Xue C, Dai Y, Chen F. Biomineralization-inspired synthesis of amorphous manganese phosphates for GLUT5-targeted drug-free catalytic therapy of osteosarcoma. Nanoscale. 2022 Jan 20;14(3):898-909.
5🏊🏼♂️、 Zhu KP, Zhang CL*#, Ma XL, Hu JP, Cai T, Zhang L. Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in OS Chemo-Resistance. Mol Ther. 2019;27(3):518-530.